Recombinant ATM antibody (AA 2550-2600)

Catalog No. ABIN7795796

This Rabbit Monoclonal antibody specifically detects ATM in WB, IHC, IP and ICC. It exhibits reactivity toward Human.

Quick Overview for Recombinant ATM antibody (AA 2550-2600) (ABIN7795796)

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ATM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: BLR359N

Product Details anti-ATM Antibody

Binding Specificity: AA 2550-2600

Purpose: Rabbit anti-ATM Recombinant Monoclonal Antibody [BLR359N]

Purification: Purified

Immunogen: between 2550 and 2600

Isotype: IgG

Application Details

Application Notes: ICC,1100 to 1500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.,IHC,1100 to 1500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.,WB,11,000,IP,6 μL/mg lysate

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1000 μg/mL

Buffer: Phosphate Buffered Saline (PBS) with 0.09 % Sodium Azide, BSA-Free

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2 - 8 °C

Expiry Date: 12 months

Target Details for ATM

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Alternative Name: ATM

Background: Ataxia telangiectasia, mutated (ATM) is the gene responsible for the neurodegenerative disease ataxia telangiectasia (AT). AT is characterized by neurodegeneration, immune dysfunction, sensitivity to DNA damage, and cancer predisposition. ATM is a protein kinase central to the DNA damage response. In response to DNA double-strand breaks (DSBs), ATM initiates a signaling cascade that involves the phosphorylation of a multitude of substrates which include p53, BRCA1, p53 binding protein, CHK2, RAD9, RAD17, and MDM4.

Gene ID: 472

UniProt: Q13315

Pathways: p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus